Endocrine Abstracts

Introduction: Subclinical hypothyroidism (SCH, higher serum thyroid stimulating hormone (TSH) with normal thyroid hormone) is associated with an increased risk of ischaemic heart disease (IHD). Subclinical thyrotoxicosis (SCT, lower serum TSH with normal thyroid hormone) is also associated with an increased risk of atrial fibrillation, cardiovascular morbidity and mortality.Aim and methods: To examine the relationship between IHD and thyroid disorders in...

Disparities in the quality of care for patients with type 1 diabetes (T1D) undergoing transition from children’s to adult services are well recognised. Poor planning and ill-defined care pathways promote patient disengagement with many becoming ‘lost’ to specialist follow-up for years. This study sought to obtain the views of young people’s experiences of transition to identify perceived barriers to an effective and rewarding transition experience. A qualit...

IntroductionThere is no consensus about biological targets in patients with central hypothyroidism (CH). The main objective of this work was to characterize our patients with CH.DesignWe conducted a retrospective study at the University Hospital of Amiens. In our center, patients with CH are considered “well substituted” if the free thyroxine (FT4) is in the upper half of the reference interval and ...

BackgroundMost post-osteoporotic fracture patients do not receive osteoporosis treatment, although it reduces risks for additional fractures. This retrospective, observational study reviewed osteoporosis evaluation and treatment following typical osteoporotic fractures.MethodsWe identified patients with hip, vertebral, humerus or radius fractures, examined in Meir Medical Center, January-December 2017. Exclus...

Thyroid hormones are important regulators of metabolism and development. Iodothyronine selenodeiodinases can both activate and inactivate thyroid hormones (Bianco et al. 2002) thus in vitro assays to quantify deiodinase inhibition are considered to be a valuable tool for studying effects on thyroid hormone metabolism by potential endocrine disruptors. The prohormone thyroxine (T4) is converted to 3, 5, 3’-triiodothyronine (T3) by outer-ring deiodination,...

IntroductionAromatase Inhibitors (AI) are standard therapy for hormone receptor positive breast cancers in post-menopausal patients. Unfortunately, resistance is common and previous studies from our lab suggest that the altered steroid environment may be a driver. Using label-free mass spectrometry we set out to explore the unique androgen receptor (AR) interactome that supervenes in AI resistant breast cancer and associated hyper-androgenic environment....

Introduction: Although breast cancer (BC) is considered a treatable disease, >30% of patients with hormone receptor positive tumours will suffer recurrence post endocrine therapy. One of the fundamental features of cancer cells is their ability to modulate cell metabolism to facilitate survival, stress response, and proliferation. Increasing evidence suggests that these mechanisms play key roles in the development of treatment resistance. Recent publicatio...

Background: Unilateral adrenal haemorrhage is usually asymptomatic and picked up incidentally on CT imaging. However, adrenal haemorrhage can cause flank pain and when bilateral, adrenal insufficiency or adrenal crisis. Biochemical changes include electrolyte imbalances, low platelet count and anaemia. We report a case of unilateral adrenal haemorrhage with devastating outcome.Case: A 45-year-old male smoker was incident...

The widespread use of cross-sectional imaging has led to increased detection of adrenal masses in 2% of general population and over 7% of those above age 70. Although majority are benign, it is important to exclude hormonally active or malignant lesions. Mild autonomous cortisol secretion (MACS) is the most common and found in 30-50% of patients with adrenal mass. We reviewed our adrenal incidentaloma database for patients who attended the nurse-led pathway for biochemistry in...

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence of the impact of BS on antenatal glycaemic control. We present three cases of pregnancy post-BS, who experienced various degrees of hypoglycaemia during gestation.Case presentations: Three women aged 25-, 26-, and 36-years-old, who were previously euglycaemic, presented to the joint antenatal clinic wi...